Nagahama Shotaro, Nishimura Ryohei, Mochizuki Manabu, Sasaki Nobuo
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Vet Anaesth Analg. 2006 May;33(3):169-74. doi: 10.1111/j.1467-2995.2005.00252.x.
To compare the constant rate infusion (CRI) of vecuronium required to maintain a level of neuromuscular blockade adequate for major surgeries, e.g. thoracotomy or laparotomy, in dogs anaesthetized with a CRI of fentanyl and either propofol, isoflurane or sevoflurane.
Prospective, randomized, cross-over study.
Thirteen male beagles (age, 9-22 months; body mass 6.3-11.3 kg).
Dogs were anaesthetized with propofol (24 mg kg(-1) hour(-1) IV CRI; group P), isoflurane (1.3% end-tidal concentration; group I) or sevoflurane (2.3% end-tidal concentration; group S) with fentanyl (5 microg kg(-1) hour(-1) IV, CRI). Sixty to seventy minutes after induction of anaesthesia, vecuronium was administered at a rate of 0.4, 0.3 and 0.2 mg kg(-1) hour(-1) in groups P, I and S respectively. To determine the degree of neuromuscular block, a peripheral nerve was stimulated electrically using the train-of-four (TO4) stimulus pattern. Evoked muscle contractions were evaluated using a neuromuscular monitoring device. Once the TO4 ratio reached 0, the continuous infusion rate was decreased and adjusted to maintain a TO4 count of 1. Continuous infusion was continued for 2 hours. The infusion rate of vecuronium was recorded 20, 40, 60, 80, 100 and 120 minutes after the start of infusion.
The mean continuous infusion rates of vecuronium during stable infusion were 0.22 +/- 0.04 (mean +/- SD), 0.10 +/- 0.02 and 0.09 +/- 0.02 mg kg(-1) hour(-1) in groups P, I and S respectively. There were statistically significant differences between the rates in groups P and I and between the rates in groups P and S. Conclusions and clinical relevance In healthy dogs, the recommended maintenance infusion rate of vecuronium is 0.2 mg kg(-1) hour(-1) under CRI propofol-fentanyl anaesthesia and 0.1 mg kg(-1) hour(-1) during CRI fentanyl-isoflurane or sevoflurane anaesthesia.
比较在以芬太尼持续输注联合丙泊酚、异氟烷或七氟烷麻醉的犬中，维持开胸术或剖腹术等大手术所需的神经肌肉阻滞水平时维库溴铵的持续输注速率（CRI）。
前瞻性、随机、交叉研究。
13只雄性比格犬（年龄9 - 22个月；体重6.3 - 11.3千克）。
犬分别用丙泊酚（静脉持续输注速率24毫克/千克/小时；P组）、异氟烷（呼气末浓度1.3%；I组）或七氟烷（呼气末浓度2.3%；S组）联合芬太尼（静脉持续输注速率5微克/千克/小时）麻醉。麻醉诱导后60至70分钟，P组、I组和S组分别以0.4、0.3和0.2毫克/千克/小时的速率给予维库溴铵。为确定神经肌肉阻滞程度，采用四个成串刺激（TO4）模式对周围神经进行电刺激。使用神经肌肉监测装置评估诱发的肌肉收缩。一旦TO4比值达到0，降低持续输注速率并调整以维持TO4计数为1。持续输注2小时。记录输注开始后20、40、60、80、100和120分钟时维库溴铵的输注速率。
稳定输注期间维库溴铵的平均持续输注速率在P组、I组和S组分别为0.22±0.04（均值±标准差）、0.10±0.02和0.09±0.02毫克/千克/小时。P组与I组以及P组与S组的速率之间存在统计学显著差异。结论及临床意义：在健康犬中，丙泊酚 - 芬太尼持续输注麻醉下维库溴铵的推荐维持输注速率为0.2毫克/千克/小时，芬太尼 - 异氟烷或芬太尼 - 七氟烷持续输注麻醉期间为0.1毫克/千克/小时。
