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Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.

作者信息

Copani A, Raciti G, Bruno V, Sortino M A, Nicoletti F, Canonico P L, Cambria A

机构信息

Istituto di Farmacologia, Facoltà di Medicina, Università di Catania.

出版信息

Ital J Biochem. 1991 Sep-Oct;40(5):289-94.

PMID:1663495
Abstract

Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.

摘要

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