Sortino M A, Nicoletti F, Canonico P L
Institute of Pharmacology, University of Catania, School of Medicine, Italy.
Eur J Pharmacol. 1990 Jul 31;189(1):115-8. doi: 10.1016/0922-4106(90)90238-s.
Inositol hexakisphosphate (InsP6) is thought to act as an intracellular signal molecule in the central nervous system. We report that InsP6 stimulates 45Ca2+ uptake in cultured anterior pituitary cells. This effect is concentration-dependent, is mimicked by inositol-pentakis phosphate (InsP5) but not by inositol-tetrakis phosphate (InsP4), is present after 2 min of incubation, is independent of extracellular Na+ and insensitive to nifedipine and verapamil. These results suggest that InsP6, a putative metabolite of the inositol cycle, may regulate transmembrane mechanism in the pituitary.
肌醇六磷酸（InsP6）被认为在中枢神经系统中作为一种细胞内信号分子发挥作用。我们报告称，InsP6刺激培养的垂体前叶细胞摄取45Ca2+。这种效应具有浓度依赖性，可被肌醇五磷酸（InsP5）模拟，但不能被肌醇四磷酸（InsP4）模拟，在孵育2分钟后出现，不依赖于细胞外Na+，并且对硝苯地平和维拉帕米不敏感。这些结果表明，InsP6作为肌醇循环的一种假定代谢产物，可能调节垂体中的跨膜机制。
