青少年特发性关节炎与牙周炎之间存在关联吗？
Is there a relationship between juvenile idiopathic arthritis and periodontitis?
作者信息
Reichert Stefan, Machulla Helmut K G, Fuchs Corinna, John Vera, Schaller Hans-Günter, Stein Jamal
机构信息
University School of Dental Medicine, Department of Operative Dentistry and Periodontology, Martin-Luther University, Halle-Wittenberg, Germany.
出版信息
J Clin Periodontol. 2006 May;33(5):317-23. doi: 10.1111/j.1600-051X.2006.00909.x.
AIM
The aim was to compare the prevalence of periodontal conditions in patients with juvenile idiopathic arthritis (JIA) (n=78, age 14.4 years) with those revealed in a healthy control group (n=75, age 15.5 years).
MATERIAL AND METHODS
In both groups, the approximal plaque index (API), the modified sulcular bleeding index (SBI), and the clinical attachment loss (CAL) were determined. Laboratory parameters for JIA activity included the capsule-reactive protein (CRP) and the immunoglobulins A, G, M.
RESULTS
JIA patients had a significantly higher API (64.6%versus 49.9%, p=0.004) and slightly higher mean percentages of sites with CAL>3.5 mm (0.58%versus 0.22%, p=0.041). There was no significant difference in the prevalence of patients and controls who had sites with CAL >3.5 mm (25.6%versus 17.3%, p=0.212). The mean CAL was slightly greater (0.2 mm; p=0.030) in patients with CRP> or =5.0 mg/l compared with patients with CRP<5.0 mg/l. Patients who took non-steroidal anti-inflammatory drugs (NSAIDs) had a significantly decreased SBI (26.2%versus 51.1%, p=0.019).
CONCLUSION
After adjustment for microbial plaque, JIA is not a risk factor for periodontitis.
目的
比较青少年特发性关节炎（JIA）患者（n = 78，年龄14.4岁）与健康对照组（n = 75，年龄15.5岁）牙周疾病的患病率。
材料与方法
两组均测定邻面菌斑指数（API）、改良龈沟出血指数（SBI）和临床附着丧失（CAL）。JIA活动的实验室参数包括血清C反应蛋白（CRP）以及免疫球蛋白A、G、M。
结果
JIA患者的API显著更高（64.6%对49.9%，p = 0.004），CAL>3.5 mm部位的平均百分比略高（0.58%对0.22%，p = 0.041）。CAL>3.5 mm部位的患者和对照组患病率无显著差异（25.6%对17.3%，p = 0.212）。与CRP<5.0 mg/l的患者相比，CRP≥5.0 mg/l的患者平均CAL略大（0.2 mm；p = 0.030）。服用非甾体抗炎药（NSAIDs）的患者SBI显著降低（26.2%对51.1%，p = 0.019）。
结论
在调整微生物菌斑后，JIA不是牙周炎的危险因素。
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