do Prado-Lima P A S, Kristensen C H, Bacaltchuck J
Behavioral Neurobiology Research Group-- Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
J Clin Pharm Ther. 2006 Apr;31(2):193-6. doi: 10.1111/j.1365-2710.2006.00716.x.
We report on a woman with borderline personality disorder and a history of childhood trauma that showed significant clinical response with low dosage of topiramate. We propose that topiramate changed some of the main features of this disorder, such as catastrophic reaction to real or imaginary abandonment or rejection, improving adaptive functioning. We hypothesize that topiramate might facilitate memory extinction, therefore decreasing emotional and behavioural reactivity.
我们报告了一名患有边缘型人格障碍且有童年创伤史的女性，她在服用低剂量托吡酯后显示出显著的临床反应。我们认为托吡酯改变了这种疾病的一些主要特征，例如对真实或想象中的抛弃或拒绝的灾难性反应，改善了适应功能。我们推测托吡酯可能促进记忆消退，从而降低情绪和行为反应性。
