托吡酯可减弱恐惧记忆的巩固并消除大鼠的条件性恐惧。
Topiramate diminishes fear memory consolidation and extinguishes conditioned fear in rats.
机构信息
Centro de Memória, Instituto do Cérebro, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Laboratório de Neurociências, Instituto de Pesquisas Biomédicas, PUCRS, Porto Alegre, Brazil.
出版信息
J Psychiatry Neurosci. 2011 Jul;36(4):250-5. doi: 10.1503/jpn.100115.
BACKGROUND
Topiramate has been recognized as a drug that can induce memory and cognitive impairment. Using the one-trial inhibitory avoidance task, we sought to verify the effect of topiramate on consolidation and extinction of aversive memory. Our hypothesis was that topiramate inhibits the consolidation and enhances the extinction of this fear memory.
METHODS
In experiment 1, which occured immediately or 3 hours after training, topiramate was administered to rats, and consolidation of memory was verified 18 days after the conditioning session. In experiment 2, which occured 18-22 days after the training session, rats were submitted to the extinction protocol. Rats received topiramate 14 days before or during the extinction protocol.
RESULTS
Topiramate blocked fear memory retention (p < 0.01) and enhanced fear memory extinction (p < 0.001) only when administered during the extinction protocol.
LIMITATIONS
This experimental design did not allow us to determine whether topiramate also blocked the reconsolidation of fear memory.
CONCLUSION
Topira mate diminishes fear memory consolidation and promotes extinction of inhibitory avoidance memory.
背景
托吡酯已被认为是一种可引起记忆和认知障碍的药物。我们使用单次抑制性回避任务来验证托吡酯对厌恶记忆的巩固和消退的影响。我们的假设是托吡酯抑制记忆的巩固并增强这种恐惧记忆的消退。
方法
在实验 1 中，在训练后立即或 3 小时给予托吡酯，并在条件反射后 18 天验证记忆的巩固。在实验 2 中，在训练后 18-22 天，对大鼠进行消退程序。在消退程序之前或期间，大鼠接受托吡酯治疗 14 天。
结果
仅当在消退程序期间给予托吡酯时，托吡酯才能阻断恐惧记忆的保留（p < 0.01）并增强恐惧记忆的消退（p < 0.001）。
局限性
这种实验设计不允许我们确定托吡酯是否也阻止了恐惧记忆的再巩固。
结论
托吡酯可减少恐惧记忆的巩固并促进抑制性回避记忆的消退。
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