Takahashi Hiroki, Chiba Hirofumi, Shiratori Masanori, Tachibana Teruo, Abe Shosaku
The Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Respirology. 2006 May;11(3):330-3. doi: 10.1111/j.1440-1843.2006.00844.x.
Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by widespread localization of calcispherites in the alveolar spaces. The authors report two cases of PAM, with markedly elevated sera concentrations of surfactant protein-A and surfactant protein-D, which showed a tendency to increase as the disease progressed. Therefore, surfactant protein-A and surfactant protein-D may function as serum markers to monitor the disease activity and progression of PAM.
肺泡微石症（PAM）是一种罕见疾病，其特征为钙球在肺泡腔内广泛沉积。作者报告了两例PAM病例，其血清表面活性蛋白A和表面活性蛋白D浓度显著升高，且随疾病进展有升高趋势。因此，表面活性蛋白A和表面活性蛋白D可能作为血清标志物用于监测PAM的疾病活动和进展。
