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腔内注射尿激酶和自体血浆：一种疏通阻塞中心静脉端口的方法。

Intraluminal instillation of urokinase and autologous plasma: a method to unblock occluded central venous ports.

作者信息

Seifert Georg, Riess Hanno, Seeger Karl, Henze Guenter, Borgmann Anja

机构信息

Department of Paediatric Oncology/Haematology, Charité--Universitätsmedizin Berlin, Germany.

出版信息

BMC Cancer. 2006 Apr 24;6:103. doi: 10.1186/1471-2407-6-103.

DOI:10.1186/1471-2407-6-103
PMID:16635269
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1501039/
Abstract

BACKGROUND

Therapeutic use and effective function of recombinant urokinase (r-UK) for occluded ports need the presence of plasminogen.

METHODS

As a therapeutic proof of principle, we demonstrate that the use of r-UK and autologous plasma effectively reestablishes the function of occluded central venous ports (CVP) resistant to routine management of catheter occlusion. Five patients with occluded ports resistant to the routine management were treated.

RESULTS

All patients were successfully treated with thrombolytic therapy using intraluminal instillation of r-UK and autologous plasma.

CONCLUSION

Instillation of r-UK and autologous plasma is a safe and effective method for management of CVP occlusion.

摘要

背景

重组尿激酶（r-UK）用于闭塞端口的治疗用途及有效功能需要纤溶酶原的存在。

方法

作为一项原理性治疗验证，我们证明使用r-UK和自体血浆可有效恢复对导管闭塞常规处理有抵抗的闭塞中心静脉端口（CVP）的功能。对5例对常规处理有抵抗的闭塞端口患者进行了治疗。

结果

所有患者均通过腔内滴注r-UK和自体血浆的溶栓治疗成功治愈。

结论

滴注r-UK和自体血浆是治疗CVP闭塞的一种安全有效的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5c0/1501039/a4183f0ba8bc/1471-2407-6-103-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5c0/1501039/a4183f0ba8bc/1471-2407-6-103-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5c0/1501039/a4183f0ba8bc/1471-2407-6-103-1.jpg

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本文引用的文献

1
Thrombolytic agents.溶栓剂。
Thromb Haemost. 2005 Apr;93(4):627-30. doi: 10.1160/TH04-11-0724.
2
Restoring patency of occluded central venous catheters.恢复阻塞的中心静脉导管的通畅性。
Arch Surg. 1980 Feb;115(2):212-3. doi: 10.1001/archsurg.1980.01380020078018.
3
Therapy for thrombotic occlusion of long-term intravenous alimentation catheters.长期静脉营养导管血栓形成闭塞的治疗
JPEN J Parenter Enteral Nutr. 1980 Jul-Aug;4(4):387-90. doi: 10.1177/014860718000400410.
4
Urokinase administration in pediatric patients with occluded central venous catheters.
J Intraven Nurs. 1990 Mar-Apr;13(2):100-2.