Glynn M F, Langer B, Jeejeebhoy K N
JPEN J Parenter Enteral Nutr. 1980 Jul-Aug;4(4):387-90. doi: 10.1177/014860718000400410.
Thrombosis and infection are closely related complications of implanted silastic catheters. A procedure, by which the thrombi are dispersed with urokinase while the catheter remains in situ, was uniformly successful in clearing the line in 20 patients, although in 5 the infusion had to be repeated 24 hr later. Catheter-associated infections are rendered susceptible to antibiotics as the infected thrombotic nidus is lysed and the organisms exposed. In 7 patients, 4 of whom were taking antibiotics, fever and blood cultures became negative. The procedure results in no detectable systemic fibrinolysis or other complications.
血栓形成和感染是硅橡胶植入导管密切相关的并发症。有一种方法，即在导管仍留在原位的情况下用尿激酶驱散血栓，该方法在20例患者中均成功清除了导管，不过有5例患者在24小时后需要重复输注。随着受感染的血栓病灶溶解且病原体暴露，与导管相关的感染变得易于用抗生素治疗。在7例患者中，其中4例正在服用抗生素，发热和血培养结果均转为阴性。该方法不会导致可检测到的全身纤维蛋白溶解或其他并发症。
