[不同阶段人类子宫内膜癌中差异基因表达的研究]
[Study of differential gene expression in different stage human endometrial cancer].
作者信息
Wan Xiao-ping, Cai Bin, Liu Ling, Xi Xiao-wei, Yang Yi-xia
机构信息
Department of Obstetrics and Gynecology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 2006 Jan;41(1):38-42.
OBJECTIVE
To study the gene expression profile of different stage endometrial cancer and identify genes related to the progression and metastasis of endometrial cancer.
METHODS
cDNA microarray was used to analyze the differentially expressed genes between different stage endometrial cancers. The hierarchical cluster analysis was applied to the gene expression profile of 32 endometrial cancers.
RESULTS
Twelve differentially expressed genes were identified between different stage endometrial cancers. The conformity rate was 66% between the result of hierarchical cluster analysis and the operative-histological stages of International Federation of Gynecology and Obstetrics (FIGO).
CONCLUSION
Genes related to the endometrial cancer progression and metastasis can be identified by differential gene expression profile with cDNA microarray and high-risk endometrial cancer may be distinguished before surgery by hierarchical cluster analysis.
目的
研究不同阶段子宫内膜癌的基因表达谱，鉴定与子宫内膜癌进展和转移相关的基因。
方法
采用cDNA微阵列分析不同阶段子宫内膜癌之间的差异表达基因。对32例子宫内膜癌的基因表达谱进行层次聚类分析。
结果
在不同阶段子宫内膜癌之间鉴定出12个差异表达基因。层次聚类分析结果与国际妇产科联盟（FIGO）手术-组织学分期的符合率为66%。
结论
通过cDNA微阵列的差异基因表达谱可鉴定与子宫内膜癌进展和转移相关的基因，术前通过层次聚类分析可能区分高危子宫内膜癌。
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