[微小RNA在子宫内膜样腺癌中的表达]
[Expression of microRNAs in endometrioid adenocarcinoma].
作者信息
Liu Xia, Xia Wei, Dai Yin-mei, Shao Ning-sheng, Zhang Wei-yuan
机构信息
Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2009 May 19;89(19):1365-7.
OBJECTIVE
To analyze miRNA expression profile of endometrioid adenocarcinoma.
METHODS
Collect Endometrium was collected from cancer and park cancer tissue. And the total RNA was extracted. The microarray detection system was employed to analyze whether there was difference in microRNA expression between cancer tissue and park cancer tissue.
RESULTS
A total of 111 differentially expressed miRNA were found, including 68 over-expression miRNA and 43 low-expression.
CONCLUSION
MiRNA may play important roles in tumorigenesis of endometrioid adenocarcinoma. The study of miRNA contributes to elucidate the molecular mechanism of endometrial cancer.
目的
分析子宫内膜样腺癌的微小RNA（miRNA）表达谱。
方法
收集癌组织及癌旁组织的子宫内膜，提取总RNA，采用基因芯片检测系统分析癌组织与癌旁组织中miRNA表达是否存在差异。
结果
共发现111个差异表达的miRNA，其中68个为高表达miRNA，43个为低表达miRNA。
结论
miRNA可能在子宫内膜样腺癌的发生中起重要作用。对miRNA的研究有助于阐明子宫内膜癌的分子机制。
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