尿碱性成纤维细胞生长因子在鉴别血管瘤与血管畸形中的作用
[Role of urinary basic fibroblast growth factor in differentiating hemangiomas from vascular malformation].
作者信息
Zhang Li, Lin Xiao-xi, Qi Zuo-liang, Dong Jia-sheng, Zou Li-jian, Dai Chuan-chang, Li Wei, Wang Wei
机构信息
Department of Plastic and Reconstructive Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
出版信息
Zhonghua Wai Ke Za Zhi. 2006 Feb 1;44(3):186-8.
OBJECTIVE
To investigate a novel method to differentiate hemangioma from vascular malformation, to stage hemangiomas and to monitor the efficacy of management for hemangioma.
METHODS
The urinary basic fibroblast growth factor (bFGF) concentration of 144 cases (including 69 cases of proliferating hemangiomas, 41 cases of involuting hemangiomas, 23 cases of vascular malformations and 11 negative controls) was examined using enzyme linked immunosorbent assay (ELISA).
RESULTS
The differences of urinary bFGF concentration among proliferating hemangiomas, involuting hemangiomas, vascular malformations and negative control were all significant, while the differences between the latter three groups were not significant.
CONCLUSIONS
Our findings suggest that examination of urinary bFGF concentration using ELISA technique is helpful in differentiating hemangioma from vascular malformation, staging hemangiomas and dynamically monitoring the efficacy of treatment for hemangiomas. Our results probably shed new light on the potential pathogenesis of hemangiomas and vascular malformation.
目的
研究一种区分血管瘤与血管畸形的新方法，对血管瘤进行分期，并监测血管瘤的治疗效果。
方法
采用酶联免疫吸附测定法（ELISA）检测144例患者（包括69例增殖期血管瘤、41例消退期血管瘤、23例血管畸形和11例阴性对照）的尿碱性成纤维细胞生长因子（bFGF）浓度。
结果
增殖期血管瘤、消退期血管瘤、血管畸形及阴性对照之间尿bFGF浓度差异均有统计学意义，而后三组之间差异无统计学意义。
结论
我们的研究结果表明，采用ELISA技术检测尿bFGF浓度有助于区分血管瘤与血管畸形，对血管瘤进行分期，并动态监测血管瘤的治疗效果。我们的结果可能为血管瘤和血管畸形的潜在发病机制提供新的线索。
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