Przewratil Przemyslaw, Sitkiewicz Anna, Wyka Krystyna, Andrzejewska Ewa
Department of Pediatric Surgery, Medical University of Lodz, Lodz, Poland.
Pediatr Dermatol. 2009 Jul-Aug;26(4):399-404. doi: 10.1111/j.1525-1470.2009.00910.x.
Impaired balance between proangiogenic and antiangiogenic factors has been implicated in the development of hemangiomas. Elevated vascular endothelial growth factor serum levels and basic fibroblastic growth factor urine levels in patients with proliferating hemangiomas were reported. However, whether these growth factors can be used for the differential diagnosis of vascular anomalies or assessment of the clinical course of hemangiomas has yet to be determined. We report here our preliminary results of serum vascular endothelial growth factor and basic fibroblastic growth factor levels as an aid in the diagnosis of hemangiomas and in the follow up of patients with this lesion. Twenty two children with infantile hemangioma (13 with proliferating hemangiomas, nine with involuting lesions), five children with vascular malformations, and 25 healthy children study group. Vascular endothelial growth factor and basic fibroblastic growth factor serum levels were analyzed by an ELISA assay. The serum vascular endothelial growth factor concentrations in children with proliferating hemangiomas were significantly higher than in patients with involuting hemangiomas, vascular malformations and healthy patients. The serum basic fibroblastic growth factor concentrations were low and similar in all patients with no statistical correlation between study groups. We concluded that (i) ELISA can easily determine vascular endothelial growth factor concentrations in different phases of hemangioma growth and help distinguishing them from vascular malformations. (ii) A potential role for vascular endothelial growth factor in the pathophysiology of hemangiomas is probable.
促血管生成因子和抗血管生成因子之间的平衡受损与血管瘤的发生发展有关。有报道称，增殖期血管瘤患者血清血管内皮生长因子水平升高，尿碱性成纤维细胞生长因子水平升高。然而，这些生长因子是否可用于血管异常的鉴别诊断或血管瘤临床病程的评估尚待确定。我们在此报告血清血管内皮生长因子和碱性成纤维细胞生长因子水平的初步结果，以辅助血管瘤的诊断及对患有该病变患者的随访。研究组包括22例患有婴儿血管瘤的儿童（13例增殖期血管瘤，9例消退期病变）、5例患有血管畸形的儿童和25例健康儿童。采用酶联免疫吸附测定法分析血管内皮生长因子和碱性成纤维细胞生长因子的血清水平。增殖期血管瘤患儿血清血管内皮生长因子浓度显著高于消退期血管瘤患儿、血管畸形患儿及健康患儿。所有患者血清碱性成纤维细胞生长因子浓度均较低且相似，研究组之间无统计学相关性。我们得出结论：（i）酶联免疫吸附测定法能够轻松测定血管瘤生长不同阶段的血管内皮生长因子浓度，并有助于将其与血管畸形区分开来。（ii）血管内皮生长因子在血管瘤病理生理学中可能具有潜在作用。
