Leppert Phyllis C, Catherino William H, Segars James H
Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Am J Obstet Gynecol. 2006 Aug;195(2):415-20. doi: 10.1016/j.ajog.2005.12.059. Epub 2006 Apr 25.
This article will discuss some recent insights based on our microarray studies that have emphasized the role the extracellular matrix, transforming growth factor beta, and collagen structure in fibroid formation. These studies led to appreciation of molecular similarities between fibroids and keloids. Collectively, these observations suggest a model of fibroid development based on an abnormal response to tissue repair, resulting in disordered healing and formation of an altered extracellular matrix.
本文将讨论基于我们的微阵列研究得出的一些最新见解，这些研究强调了细胞外基质、转化生长因子β和胶原蛋白结构在肌瘤形成中的作用。这些研究使人们认识到肌瘤和瘢痕疙瘩之间的分子相似性。总体而言，这些观察结果提示了一种基于对组织修复的异常反应的肌瘤发育模型，导致愈合紊乱和细胞外基质改变的形成。
