三个基因组的故事：动质体来了。

A tale of three genomes: the kinetoplastids have arrived.

作者信息

Kissinger Jessica C

机构信息

Department of Genetics and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30606, USA.

出版信息

Trends Parasitol. 2006 Jun;22(6):240-3. doi: 10.1016/j.pt.2006.04.002. Epub 2006 Apr 25.

DOI:10.1016/j.pt.2006.04.002

PMID:16635586

Abstract

July 2005 marked a milestone in kinetoplastid biology research. A tour de force effort led by the Tri-Trypanosomatidae "Tritryp" genome consortium yielded the publication of three prominent kinetoplastid parasite genome sequences: Trypanosoma brucei, Trypanosoma cruzi and Leishmania major. The individual and combined comparative analyses of these three genome sequences, combined with proteomic analyses, have yielded insights into topics ranging from genome evolution and horizontal gene transfer to potential new therapeutic and vaccine targets.

摘要

2005年7月标志着动质体生物学研究的一个里程碑。由三锥虫科（Tri-Trypanosomatidae）“三锥虫（Tritryp）”基因组联盟牵头的一项艰巨努力，促成了三篇关于重要动质体寄生虫基因组序列的论文发表：布氏锥虫（Trypanosoma brucei）、克氏锥虫（Trypanosoma cruzi）和硕大利什曼原虫（Leishmania major）。对这三个基因组序列进行的单独及综合比较分析，再结合蛋白质组学分析，为从基因组进化和水平基因转移到潜在的新治疗和疫苗靶点等一系列主题提供了深刻见解。