脊髓损伤后快速且广泛的动脉适应性变化。

Rapid and extensive arterial adaptations after spinal cord injury.

作者信息

de Groot Patricia C, Bleeker Michiel W, van Kuppevelt Dirk H, van der Woude Luc H, Hopman Maria T

机构信息

Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

出版信息

Arch Phys Med Rehabil. 2006 May;87(5):688-96. doi: 10.1016/j.apmr.2006.01.022.

DOI:10.1016/j.apmr.2006.01.022

PMID:16635632

Abstract

OBJECTIVE

To assess the time course of adaptations in leg vascular dimension and function within the first 6 weeks after a spinal cord injury (SCI).

DESIGN

Longitudinal study design.

SETTING

University medical center and rehabilitation clinic.

PARTICIPANTS

Six men were studied serially at 1, 2, 3, 4, and 6 weeks after SCI.

INTERVENTIONS

Not applicable.

MAIN OUTCOME MEASURES

Diameter, blood flow, and shear rate levels of the common femoral artery (CFA), superficial femoral artery (SFA), brachial artery, and carotid artery were measured with echo Doppler ultrasound (diameter, blood flow, shear rate). Endothelial function in the SFA was measured with flow-mediated dilation (FMD). In addition, leg volume and blood pressure measurements were performed.

RESULTS

Femoral artery diameter (CFA, 25%; SFA, 16%; P<.01) and leg volume (22%, P<.01) decreased simultaneously, and these reductions were largely accomplished within 3 weeks postinjury. Significant increases were observed for basal shear rate levels (64% increase at week 3; 117% increase at week 6; P<.01), absolute FMD responses (8% increase at week 3, 23% increase at week 6; P<.05) and relative FMD responses (26% increase at week 3, 44% increase at week 6; P<.001).

CONCLUSIONS

Our findings show a rapid onset of adaptations in arterial dimension and function to extreme inactivity in humans. Vascular adaptations include extensive reductions in femoral diameter and leg volume, as well as increased basal shear rate levels and FMD responses, which all appear to be largely accomplished within 3 weeks after an SCI.

摘要

目的

评估脊髓损伤（SCI）后前6周内腿部血管尺寸和功能的适应时间进程。

设计

纵向研究设计。

地点

大学医学中心和康复诊所。

参与者

6名男性在SCI后1、2、3、4和6周进行了连续研究。

干预措施

不适用。

主要观察指标

使用超声多普勒（直径、血流量、剪切速率）测量股总动脉（CFA）、股浅动脉（SFA）、肱动脉和颈动脉的直径、血流量和剪切速率水平。通过血流介导的血管舒张（FMD）测量SFA的内皮功能。此外，还进行了腿部体积和血压测量。

结果

股动脉直径（CFA，25%；SFA，16%；P<0.01）和腿部体积（22%，P<0.01）同时下降，这些下降在损伤后3周内基本完成。基础剪切速率水平显著增加（第3周增加64%；第6周增加117%；P<0.01），绝对FMD反应（第3周增加8%，第6周增加23%；P<0.05）和相对FMD反应（第3周增加26%，第6周增加44%；P<0.001）。