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高危人群中侵袭性黑色素瘤的表现与检测

Presentation and detection of invasive melanoma in a high-risk population.

作者信息

McPherson Michelle, Elwood Mark, English Dallas R, Baade Peter D, Youl Philippa H, Aitken Joanne F

机构信息

Queensland Cancer Fund, Brisbane, Australia.

出版信息

J Am Acad Dermatol. 2006 May;54(5):783-92. doi: 10.1016/j.jaad.2005.08.065.

DOI:10.1016/j.jaad.2005.08.065
PMID:16635658
Abstract

BACKGROUND

Early detection of melanoma has been encouraged in Queensland for many years, yet little is known about the patterns of detection and the way in which they relate to tumor thickness.

OBJECTIVE

Our purpose was to describe current patterns of melanoma detection in Queensland.

METHODS

This was a population-based study, comprising 3772 Queensland residents diagnosed with a histologically confirmed melanoma between 2000 and 2003.

RESULTS

Almost half (44.0%) of the melanomas were detected by the patients themselves, with physicians detecting one fourth (25.3%) and partners one fifth (18.6%). Melanomas detected by doctors were more likely to be thin (<0.75 mm) than those detected by the patient or other layperson. Melanomas detected during a deliberate skin examination were thinner than those detected incidentally.

LIMITATIONS

Although a participation rate of 78% was achieved, as in any survey, nonresponse bias cannot be completely excluded, and the ability of the results to be generalized to other geographical areas is unknown.

CONCLUSION

There are clear differences in the depth distribution of melanoma in terms of method of detection and who detects the lesions that are consistent with, but do not automatically lead to, the conclusion that promoting active methods of detection may be beneficial.

摘要

背景

多年来昆士兰州一直鼓励早期发现黑色素瘤,但对于其发现模式以及这些模式与肿瘤厚度的关系却知之甚少。

目的

我们的目的是描述昆士兰州目前黑色素瘤的发现模式。

方法

这是一项基于人群的研究,纳入了2000年至2003年间被诊断为经组织学确诊黑色素瘤的3772名昆士兰州居民。

结果

几乎一半(44.0%)的黑色素瘤是由患者自己发现的,医生发现的占四分之一(25.3%),伴侣发现的占五分之一(18.6%)。医生发现的黑色素瘤比患者或其他非专业人员发现的更可能是薄型的(<0.75 mm)。在有意进行皮肤检查期间发现的黑色素瘤比偶然发现的更薄。

局限性

尽管参与率达到了78%,但与任何调查一样,无法完全排除无应答偏倚,且结果能否推广到其他地理区域尚不清楚。

结论

黑色素瘤在深度分布方面,根据发现方法以及发现病变的人员不同存在明显差异,这与促进积极的发现方法可能有益这一结论相符,但并非必然得出该结论。

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