Wu Chi-Chen, Mok Martin S, Chen Jui-Yuan, Wu Gong-Jhe, Wen Yeong-Ray, Lin Chao-Shun
Department of Anesthesiology, Taipei Medical University Hospital, 252 Wu-Hsin Street, Taipei, Taiwan 110.
Can J Anaesth. 2006 May;53(5):456-60. doi: 10.1007/BF03022617.
A randomized, double blind controlled trial was undertaken to investigate the effect of doxapram on recovery times and bispectral index following sevoflurane anesthesia.
Upon completion of surgery under sevoflurane anesthesia, 60 adult patients were randomly allocated to receive either doxapram hydrochloride 1 mg.kg(-1) iv or saline placebo. Clinical recovery from anesthesia was assessed by time to eye opening on verbal command, hand squeezing on command, time to extubation, and the Aldrete recovery score. Bispectral index values, systolic blood pressure, and heart rate were recorded at baseline (before anesthesia), during surgery, and every minute for 15 min after administration of the study drug.
Time to eye opening was shorter in the doxapram group compared with the control group (6.9 +/- 2.2 min vs 9.9 +/- 3.1 min, P < 0.05). Mean bispectral index scores were also higher in the doxapram group compared with the saline placebo seven to eight minutes following administration of the study medication (P < 0.05). More rapid emergence was associated with a greater increase in heart rate with doxapram (P < 0.05 compared with placebo), but no differences in systolic blood pressure responses were observed in comparison with placebo.
We conclude that doxapram 1 mg.kg(-1) hastens early recovery from sevoflurane anesthesia, and this arousal effect correlates with higher bispectral index values.
进行一项随机双盲对照试验，以研究多沙普仑对七氟醚麻醉后恢复时间和脑电双频指数的影响。
60例成年患者在七氟醚麻醉下完成手术后，随机分配接受静脉注射1mg.kg(-1)盐酸多沙普仑或生理盐水安慰剂。通过对言语指令睁眼时间、指令下握力、拔管时间和Aldrete恢复评分来评估麻醉后的临床恢复情况。在基线（麻醉前）、手术期间以及给予研究药物后15分钟内每分钟记录脑电双频指数值、收缩压和心率。
多沙普仑组的睁眼时间比对照组短（6.9±2.2分钟对9.9±3.1分钟，P<0.05）。给予研究药物后7至8分钟，多沙普仑组的平均脑电双频指数评分也高于生理盐水安慰剂组（P<0.05）。多沙普仑使苏醒更快，且心率增加更大（与安慰剂相比P<0.05），但与安慰剂相比，收缩压反应无差异。
我们得出结论，1mg.kg(-1)多沙普仑可加速七氟醚麻醉后的早期恢复，且这种苏醒作用与更高的脑电双频指数值相关。
