霉酚酸酯治疗皮肌炎：安全吗？
Mycophenolate mofetil in dermatomyositis: is it safe?
作者信息
Rowin J, Amato A A, Deisher N, Cursio J, Meriggioli M N
机构信息
Department of Neurology and Rehabilitation, University of Illinois, Chicago, IL 60612-7330, USA.
出版信息
Neurology. 2006 Apr 25;66(8):1245-7. doi: 10.1212/01.wnl.0000208416.32471.c0.
Abstract
The authors report 10 patients with idiopathic dermatomyositis treated with mycophenolate mofetil in combination with corticosteroids. Successful steroid taper without disease relapse was achieved in six patients; however, in three patients, treatment was associated with opportunistic infections, leading to death in one patient. The disproportionately high rate of opportunistic infections in this group is considered.
摘要
作者报告了10例接受霉酚酸酯联合皮质类固醇治疗的特发性皮肌炎患者。6例患者成功减少了类固醇用量且疾病未复发；然而，3例患者出现了机会性感染，其中1例患者死亡。本文考虑了该组中机会性感染发生率过高的情况。
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