Antonopoulos Ioannis, Liossis Stamatis-Nick
Patras University Hospital, Department of Internal Medicine, Division of Rheumatology, Rion, Patras, Greece.
Univerity of Patras Medical School, Rion, Patras, Greece.
Mediterr J Rheumatol. 2018 Dec 18;29(4):221-223. doi: 10.31138/mjr.29.4.221. eCollection 2018 Dec.
Dermatomyositis is an idiopathic inflammatory disorder of the muscles associated with characteristic cutaneous findings. Herein we report a 68-year old woman who presented with dermatomyositis associated with painful vasculitic lesions on both hands, refractory to conventional treatment. Steroids, topical tacrolimus, antimalarials and intravenous cyclophosphamide were tried with no beneficial effect. Rituximab was also administered with no initial effect; soon afterwards, intravenous immunoglobulin was administered with good results. Some cases of cutaneous dermatomyositis may require trials of different therapies to identify the treatment regimen that produces satisfactory disease control.
皮肌炎是一种与特征性皮肤表现相关的特发性肌肉炎性疾病。在此，我们报告一名68岁女性，她患有皮肌炎，双手出现疼痛性血管炎性病变，对传统治疗无效。曾尝试使用类固醇、外用他克莫司、抗疟药和静脉注射环磷酰胺，但均无有益效果。使用利妥昔单抗也未见初始疗效；此后不久，静脉注射免疫球蛋白取得了良好效果。一些皮肤型皮肌炎病例可能需要尝试不同的治疗方法，以确定能实现满意疾病控制的治疗方案。
