Sadleir Rosalind, Grant Samuel, Zhang Sung Uk, Oh Suk Hoon, Lee Byung Il, Woo Eung Je
Department of Biomedical Engineering, University of Florida, USA.
Physiol Meas. 2006 May;27(5):S261-70. doi: 10.1088/0967-3334/27/5/S22. Epub 2006 Apr 24.
Magnetic resonance electrical impedance tomography (MREIT) has the potential to provide conductivity and current density images with high spatial resolution and accuracy. Recent experimental studies at a field strength of 3 T showed that the spatial resolution of conductivity and current density images may be similar to that of conventional MR images as long as enough current is injected, at least 20 mA when the object being imaged has a size similar to the human head. To apply the MREIT technique to image small conductivity changes using less injection current, we performed MREIT studies at 11 T field strength, where noise levels in measured magnetic flux density data are significantly lower. In this paper we present the experimental results of imaging biological tissues with different conductivity values using MREIT at 11 T. We describe technical difficulties encountered in using high-field MREIT systems and possible solutions. High-field MREIT is suggested as a research tool for obtaining accurate conductivity data from tissue samples and animal subjects.
磁共振电阻抗断层成像（MREIT）有潜力提供具有高空间分辨率和准确性的电导率和电流密度图像。最近在3T场强下进行的实验研究表明，只要注入足够的电流，电导率和电流密度图像的空间分辨率可能与传统磁共振图像相似，当被成像物体的尺寸与人头相似时，至少需要20mA。为了应用MREIT技术以较少的注入电流对小的电导率变化进行成像，我们在11T场强下进行了MREIT研究，在该场强下测量的磁通密度数据中的噪声水平显著更低。在本文中，我们展示了在11T场强下使用MREIT对具有不同电导率值的生物组织进行成像的实验结果。我们描述了使用高场MREIT系统时遇到的技术难题及可能的解决方案。高场MREIT被认为是一种从组织样本和动物受试者获取准确电导率数据的研究工具。
