Ohsaki Yusuke, Shirakawa Hitoshi, Hiwatashi Kazuyuki, Furukawa Yuji, Mizutani Takeo, Komai Michio
Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University , Sendai, Japan.
Biosci Biotechnol Biochem. 2006 Apr;70(4):926-32. doi: 10.1271/bbb.70.926.
Vitamin K (K) is essential for blood coagulation and bone metabolism in mammals. K acts as a cofactor in the posttranslational synthesis of gamma-carboxyglutamic acid from glutamic acid residues. In addition to the liver and bone, K is found in the brain, heart, kidney and gonadal tissue. However, the physiological role of K in these various organs is not yet fully understood. It is likely that K has functions other than its role as a cofactor of protein gamma-glutamyl carboxylation. We used in this study the DNA microarray technique to identify the effect of K status on gene expression in the rat liver. The expression of genes involved in the acute inflammation response was enhanced in rats fed with a K-deficient diet relative to the control and K1-supplemented diet groups. Moreover, dietary supplementation with K1 suppressed the inflammation induced by lipopolysaccharide administration. These results indicate that orally administrated K1 suppressed inflammation in the rat.
维生素K（K）对哺乳动物的血液凝固和骨骼代谢至关重要。K在从谷氨酸残基进行γ-羧基谷氨酸的翻译后合成过程中作为一种辅助因子。除了肝脏和骨骼外，在大脑、心脏、肾脏和性腺组织中也发现了K。然而，K在这些不同器官中的生理作用尚未完全明确。K可能具有除作为蛋白质γ-谷氨酰羧化辅助因子之外的其他功能。在本研究中，我们使用DNA微阵列技术来确定K状态对大鼠肝脏基因表达的影响。与对照组和补充K1饮食组相比，喂食缺K饮食的大鼠中参与急性炎症反应的基因表达增强。此外，补充K1饮食可抑制脂多糖给药诱导的炎症。这些结果表明，口服K1可抑制大鼠体内的炎症。
