Aborode Abdullahi T, Onifade Isreal A, Olorunshola Mercy M, Adenikinju Gladys O, Aruorivwooghene Ibude J, Femi Adeboboye C, Osayawe Osasere Jude-Kelly, Osinuga Abraham, Omojowolo Ebenezer A, Adeoye Adekunle F, Olapade Segun, Adelakun Ibrahim O, Moyinoluwa Ogundepo D, Adeyemo Oluwatosin M, Scott Godfred Y, Ogbonna Ruth A, Fajemisin Emmanuel A, Ehtasham Omama, Toluwalashe Soyemi, Bakre Adetolase A, Adesola Ridwan O, Ogunleye Seto C, Anyanwu Nnenna R, Iorkula Terungwa H
Department of Chemistry, Mississippi State University, Starkville, MS 39759, USA.
Department of Biology, University at Albany, Albany, NY 12222, USA.
Cancer Pathog Ther. 2024 May 16;3(1):3-15. doi: 10.1016/j.cpt.2024.05.001. eCollection 2025 Jan.
Recently, the potential role of vitamins in cancer therapy has attracted considerable research attention. However, the reported findings are inconsistent, with limited information on the biochemical and molecular interactions of different vitamins in various cancer cells. Importantly, the presence of vitamin receptors in tumor cells suggests that vitamins play a significant role in the molecular and biochemical interactions in cancers. Additionally, studies on the efficacy of vitamin supplementation and dosage levels on tumor progression and mortality risk have yielded inconsistent results. Notably, molecular and biochemical investigations have reported the function of vitamins in the proliferation, growth, and invasiveness of tumor cells, as well as in cell cycle arrest and inflammatory signaling. Additionally, different vitamins may regulate the cancer microenvironment by activating various molecular pathways. Vitamins significantly affect immunological function, antioxidant defense, inflammation, and epigenetic control, and can improve treatment outcomes by affecting cell behavior and combating stress and DNA damage. However, further research is necessary to confirm the efficacy of vitamins, establish ideal dosages, and develop effective cancer prevention and treatment plans. Individualized supplementation plans guided by medical knowledge are crucial to achieving optimal results in clinical and preclinical settings. In this review, we critically evaluated the effects of different vitamins on the risk and development of cancer. Additionally, we examined the potential of vitamin supplements to enhance the efficacy of drug therapy and counteract resistance mechanisms that often arise during cancer treatment.
最近，维生素在癌症治疗中的潜在作用已引起了相当多的研究关注。然而，所报道的研究结果并不一致，关于不同维生素在各种癌细胞中的生化和分子相互作用的信息有限。重要的是，肿瘤细胞中维生素受体的存在表明维生素在癌症的分子和生化相互作用中发挥着重要作用。此外，关于维生素补充剂的疗效以及剂量水平对肿瘤进展和死亡风险的影响的研究结果也不一致。值得注意的是，分子和生化研究报告了维生素在肿瘤细胞的增殖、生长和侵袭性以及细胞周期停滞和炎症信号传导中的作用。此外，不同的维生素可能通过激活各种分子途径来调节癌症微环境。维生素显著影响免疫功能、抗氧化防御、炎症和表观遗传控制，并可通过影响细胞行为以及对抗应激和DNA损伤来改善治疗效果。然而，需要进一步的研究来证实维生素的疗效，确定理想的剂量，并制定有效的癌症预防和治疗方案。以医学知识为指导的个性化补充方案对于在临床和临床前环境中取得最佳效果至关重要。在这篇综述中，我们批判性地评估了不同维生素对癌症风险和发展的影响。此外，我们研究了维生素补充剂增强药物治疗疗效以及抵消癌症治疗过程中经常出现的耐药机制的潜力。
