[Antithrombotic effects of molsidomine alone and in combination with other antithrombotic agents in a thrombosis model of the microcirculation of the rat].

The antithrombotic effect of Molsidomin and other different antithrombotic agents have been investigated alone and in combinations in a thrombosis model in rats in which mesenteric vessels with a diameter of 20-30 microns were injured by defined argon laser lesions. In this animal thrombosis model all agents showed a significant and dose-dependent antithrombotic effect. A strong additive effect was observed when Molsidomin was infused together with Cicaprost. A similar additive effect was observed after administration Molsidomin together with heparins. The combination of a minimal effective dose of Molsidomin with Aprosulate also had a significant additive effect. After application of Molsidomin together with a TXA2 receptor antagonists a slight additive antithrombotic effect was observed.