Giedrojc J, Weichert W, Breddin H K
Abteilung für Angiologie, Zentrum der Inneren Medizin, J.W. Goethe-Universität, Frankfurt/Main.
Z Kardiol. 1991;80 Suppl 5:35-9.
The antithrombotic effect of Molsidomin and other different antithrombotic agents have been investigated alone and in combinations in a thrombosis model in rats in which mesenteric vessels with a diameter of 20-30 microns were injured by defined argon laser lesions. In this animal thrombosis model all agents showed a significant and dose-dependent antithrombotic effect. A strong additive effect was observed when Molsidomin was infused together with Cicaprost. A similar additive effect was observed after administration Molsidomin together with heparins. The combination of a minimal effective dose of Molsidomin with Aprosulate also had a significant additive effect. After application of Molsidomin together with a TXA2 receptor antagonists a slight additive antithrombotic effect was observed.
已在大鼠血栓形成模型中单独及联合研究了吗多明和其他不同抗血栓药物的抗血栓作用，该模型中直径20 - 30微米的肠系膜血管通过特定的氩激光损伤。在这个动物血栓形成模型中，所有药物均显示出显著的剂量依赖性抗血栓作用。当吗多明与西卡前列素一起输注时，观察到强烈的相加作用。吗多明与肝素联合给药后也观察到类似的相加作用。吗多明最小有效剂量与阿普舒拉的组合也有显著的相加作用。吗多明与血栓素A2受体拮抗剂联合应用后观察到轻微的相加抗血栓作用。
