Lasa Iñigo
Laboratory of Microbial Biofilms, Institute of Agrobiotechnology and Department of Agrarian Production, Public University of Navarra-CSIC, Pamplona, Spain.
Int Microbiol. 2006 Mar;9(1):21-8.
Microorganisms can live and proliferate as individual cells swimming freely in the environment, or they can grow as highly organized, multicellular communities encased in a self-produced polymeric matrix in close association with surfaces and interfaces. This microbial lifestyle is referred to as biofilms. The intense search over the last few years for factors involved in biofilm development has revealed that distantly related bacterial species recurrently make use of the same elements to produce biofilms. These common elements include a group of proteins containing GGDEF/EAL domains, surface proteins homologous to Bap of Staphylococcus aureus, and some types of exopolysaccharides, such as cellulose and the poly-beta-1,6-N-acetylglucosamine. This review summarizes current knowledge about these three common elements and their role in biofilm development.
微生物能够以单个细胞的形式在环境中自由游动生存和增殖，或者它们可以形成高度有组织的多细胞群落，包裹在自身产生的聚合物基质中，与表面和界面紧密相连。这种微生物生活方式被称为生物膜。在过去几年中，对参与生物膜形成的因素进行的深入研究表明，亲缘关系较远的细菌物种经常利用相同的成分来产生生物膜。这些共同的成分包括一组含有GGDEF/EAL结构域的蛋白质、与金黄色葡萄球菌Bap同源的表面蛋白，以及一些类型的胞外多糖，如纤维素和聚-β-1,6-N-乙酰葡糖胺。这篇综述总结了关于这三种常见成分及其在生物膜形成中作用的当前知识。
