Fukunaga Takashi, Soejima Hirofumi, Sugamura Koichi, Kojima Sunao, Sugiyama Seigo, Sakamoto Tomohiro, Yoshimura Michihiro, Tanoue Toshihide, Kageshita Toshiro, Ono Tomomichi, Ogawa Hisao
Departments of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto.
J Cardiol. 2006 Apr;47(4):191-5.
A 61-year-old woman with stage IV malignant melanoma suffered acute myocardial infarction during the third course of chemotherapy with cisplatin, dacarbazine, nimustine hydrochloride and tamoxifen citrate, despite no serious problem occurring during the first and second courses of chemotherapy. Since this patient, excluding menopause, had no significant risk factor for coronary heart disease before the start of chemotherapy, the infarction was likely to be attributable to the chemotherapy regimen. Chemotherapy should be used cautiously in patients with coronary risk factors before treatment is begun.
一名61岁的IV期恶性黑色素瘤女性患者，在接受顺铂、达卡巴嗪、盐酸尼莫司汀和枸橼酸他莫昔芬的第三个化疗疗程时发生急性心肌梗死，尽管在前两个化疗疗程中未出现严重问题。由于该患者在化疗开始前，除绝经外没有明显的冠心病危险因素，所以心肌梗死很可能归因于化疗方案。对于有冠心病危险因素的患者，在开始治疗前应谨慎使用化疗。
