Korytina G F, Akhmadishina L Z, Ianbaeva D G, Viktorova T V
Mol Biol (Mosk). 2006 Mar-Apr;40(2):231-8.
The distribution of alleles and genotypes of vitamin D-binding protein (DBP) gene has been studied in patients with Chronic Obstructive Pulmonary Disease (COPD, n = 298) and healthy individuals (n = 237) from two ethnic groups (Tatars and Russians) living in Republic Bashkortostan. Statistically significant differences in the distribution of DBP gene genotypes between Tatars and Russians (chi2 = 8.854, df = 5, P = 0.04) were revealed. The pattern of allele's distribution within DBP gene was similar in healthy control subjects of both ethnic groups, with gradient reduction in row GC1S> GC1F> GC2. The most common genotypes were: GC1F/1S in Tatars (36.79%) and GC1S/2 in Russians (34.62%). It has been shown, that Tatars with genotype GC1F/1S have a lower risk of COPD development: the frequency of GC1F/1S genotype in COPD patients was significantly lower than in healthy individuals (19.85% versus 36.79%; chi2 = 7.622, P = 0.0067, Pcor = 0.0335; OR = 0.42 CI 95% 0.22-0.79). At the same time, COPD patients from the same group had higher frequency of GC 1F/2 genotype than healthy individuals (19.08% versus 8.49%; chi2 = 4.52, P = 0.033, Pcor = 0.165; OR = 2.54 CI 95% 1.067-6.20). In Russian population the distribution of alleles and genotypes of DBP gene were similar in COPD patients and healthy individuals.
对生活在巴什科尔托斯坦共和国的两个民族（鞑靼族和俄罗斯族）的慢性阻塞性肺疾病患者（COPD，n = 298）和健康个体（n = 237）的维生素D结合蛋白（DBP）基因的等位基因和基因型分布进行了研究。结果显示，鞑靼族和俄罗斯族之间DBP基因基因型分布存在统计学显著差异（卡方 = 8.854，自由度 = 5，P = 0.04）。两个民族健康对照者中DBP基因内等位基因的分布模式相似，呈GC1S> GC1F> GC2的梯度递减。最常见的基因型为：鞑靼族中GC1F/1S（36.79%），俄罗斯族中GC1S/2（34.62%）。研究表明，基因型为GC1F/1S的鞑靼族患COPD的风险较低：COPD患者中GC1F/1S基因型的频率显著低于健康个体（19.85%对36.79%；卡方 = 7.622，P = 0.0067，校正P = 0.0335；比值比 = 0.42，95%置信区间0.22 - 0.79）。同时，同一组的COPD患者中GC 1F/2基因型的频率高于健康个体（19.08%对8.49%；卡方 = 4.52，P = 0.033，校正P = 0.165；比值比 = 2.54，95%置信区间1.067 - 6.20）。在俄罗斯人群中，COPD患者和健康个体的DBP基因等位基因和基因型分布相似。
