全身应用5-氟尿嘧啶后出现多发性甲周化脓性肉芽肿。

Multiple periungual pyogenic granulomas following systemic 5-fluorouracil.

作者信息

Curr Nathan, Saunders Helen, Murugasu Anand, Cooray Prasad, Schwarz Max, Gin Douglas

机构信息

Department of Dermatology, The Alfred Hospital, Prahran, Victoria, Australia.

出版信息

Australas J Dermatol. 2006 May;47(2):130-3. doi: 10.1111/j.1440-0960.2006.00248.x.

DOI:10.1111/j.1440-0960.2006.00248.x

PMID:16637811

Abstract

A 65-year-old man presented with a 7-month history of eight bleeding periungual lesions on both feet. The clinical diagnosis of multiple pyogenic granulomas was confirmed by histological examination. Historically, the pyogenic granulomas appeared 3 months after commencing 5-fluorouracil chemotherapy for rectal carcinoma, suggesting a possible causative relationship. Chemotherapy was ceased by the supervising oncologist. Resolution occurred after two lesions had been treated with curettage and diathermy, and the remaining lesions with occlusive dressings over Kenacomb ointment (triamcinolone acetonide 0.1%, neomycin sulphate 0.25%, gramicidin 0.025%, nystatin 100,000 U/g) topically twice daily for a period of 3 months.

摘要

一名65岁男性患者，双脚出现8个甲周出血性损害，病程7个月。组织学检查确诊为多发性化脓性肉芽肿。既往史显示，这些化脓性肉芽肿在开始针对直肠癌的5-氟尿嘧啶化疗3个月后出现，提示可能存在因果关系。主治肿瘤学家停用了化疗。对两个损害进行刮除术和透热疗法后病变消退，其余损害每日两次外用覆盖在复方康纳乐霜（曲安奈德0.1%、硫酸新霉素0.25%、短杆菌肽0.025%、制霉菌素100,000 U/g）上的封闭敷料，持续3个月。