Teknetzis A, Ioannides D, Vakali G, Lefaki I, Minas A
Department of Dermatology, Aristotle University Medical School, 6 Makenzy King Street, 54622 Thessaloniki, Greece.
J Eur Acad Dermatol Venereol. 2004 May;18(3):337-9. doi: 10.1111/j.1468-3083.2004.00821.x.
Topical tretinoin is used in the treatment of acne and other dermatoses. The most common side-effects are itching, dryness and reddening of the skin. We report an additional cutaneous reaction, which occurred in patients using topical tretinoin. Pyogenic granulomas developed in two patients with acne and in one with dermatofibroma following application of tretinoin. The granulomas grew on the lesions after 2-3 weeks of therapy initiation. All patients were men and the granulomas developed in their trunk. The lesions resolved when topical tretinoin was ceased. Although the number of patients reported is too small to estimate the true incidence of this reaction, it is likely that dermatologists will encounter similar reactions in patients treated with topical tretinoin for acne or other reasons.
外用维甲酸用于治疗痤疮和其他皮肤病。最常见的副作用是皮肤瘙痒、干燥和发红。我们报告了一种外用维甲酸患者发生的额外皮肤反应。两名痤疮患者和一名皮肤纤维瘤患者在使用维甲酸后出现了化脓性肉芽肿。肉芽肿在开始治疗2 - 3周后在皮损处生长。所有患者均为男性，肉芽肿发生在躯干。停用外用维甲酸后皮损消退。虽然报告的患者数量太少，无法估计这种反应的真实发生率，但皮肤科医生在治疗痤疮或其他原因而使用外用维甲酸的患者中可能会遇到类似反应。
