Yamada Masakazu, Ishikawa Kaoru, Mochizuki Hiroshi, Kawai Masataka
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Acta Ophthalmol Scand. 2006 Apr;84(2):192-6. doi: 10.1111/j.1600-0420.2005.00561.x.
This study was performed to assess the corneal penetration of three topically applied fluoroquinolones (levofloxacin, norfloxacin and lomefloxacin) in corneal buttons obtained from patients undergoing penetrating keratoplasty.
Fourteen patients received three drops each of 0.5% levofloxacin, 0.3% norfloxacin and 0.3% lomefloxacin (the standard clinically available preparations) over a 30-min interval beginning 90 mins before their scheduled keratoplasty. Corneal samples obtained from excised buttons at the time of surgery were stored at - 80 degrees until analysis. The concentration of the administered fluoroquinolones was measured using high-performance liquid chromatography.
The mean corneal concentration of levofloxacin (4.6 +/- 3.5 microg/g, mean +/- standard deviation) was significantly higher than that of lomefloxacin (2.7 +/- 1.8 microg/g, p = 0.0018) and norfloxacin (1.3 +/- 1.2 microg/g, p = 0.00012).
Levofloxacin achieves a higher mean corneal concentration than norfloxacin and lomefloxacin in the human cornea.
本研究旨在评估三种局部应用的氟喹诺酮类药物（左氧氟沙星、诺氟沙星和洛美沙星）在穿透性角膜移植患者角膜片中的角膜穿透性。
14例患者在预定角膜移植手术前90分钟开始，在30分钟内每隔一段时间各滴入三滴0.5%左氧氟沙星、0.3%诺氟沙星和0.3%洛美沙星（临床可用的标准制剂）。手术时从切除的角膜片中获取的角膜样本在-80摄氏度下保存直至分析。使用高效液相色谱法测量所给予的氟喹诺酮类药物的浓度。
左氧氟沙星的平均角膜浓度（4.6±3.5微克/克，平均值±标准差）显著高于洛美沙星（2.7±1.8微克/克，p = 0.0018）和诺氟沙星（1.3±1.2微克/克，p = 0.00012）。
在人角膜中，左氧氟沙星的平均角膜浓度高于诺氟沙星和洛美沙星。
