Wunderink A, Nienhuis F J, Sytema S, Wiersma D
Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Acta Psychiatr Scand. 2006 Apr;113(4):332-9. doi: 10.1111/j.1600-0447.2005.00685.x.
There is no consistent evidence of long duration of untreated psychosis (DUP) predicting long time to response (TTR) in first psychosis. This study aims to investigate the predictors of DUP and TTR in a first episode patient population.
An epidemiologically representative sample of 157 non-affective first psychotic episode patients was interviewed and followed-up for at least half a year.
The mean DUP was 46 weeks, the median 31 days. Long DUP was associated with being unemployed before treatment and male gender. Short DUP, having a job, and living with a partner before treatment predicted early response.
Early intervention likely improves short-term treatment response in first episode psychosis. The best strategy to reduce DUP probably is to direct attention to the substantial number of patients who do not engage in regular treatment.
尚无一致证据表明首次发作精神病时未治疗精神病持续时间（DUP）可预测长时间才能起效（TTR）。本研究旨在调查首发患者群体中DUP和TTR的预测因素。
对157例非情感性首次精神病发作患者进行了具有流行病学代表性的抽样访谈，并随访至少半年。
DUP的平均时长为46周，中位数为31天。较长的DUP与治疗前失业及男性性别相关。较短的DUP、有工作以及治疗前与伴侣同住可预测早期起效。
早期干预可能改善首次发作精神病的短期治疗反应。减少DUP的最佳策略可能是将注意力转向大量未接受正规治疗的患者。
