Apiquián-Guitart Rogelio, Fresán-Orellana Ana, García-Anaya Maria, Lóyzaga-Mendoza Cristina, Nicolini-Sánchez Humberto
Subdirección de Psiquiatría, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, Mexico DF, México.
Gac Med Mex. 2006 Mar-Apr;142(2):113-20.
The delay on the onset of specific treatment has several prognostic implications for psychotic patients. Duration of untreated psychosis (DUP) has been considered a prognostic variable. A longer DUP has been associated with a poor clinical outcome.
To determine the DUP in a sample of first-episode psychotic patients and its relationship with recovery and relapse on a one-year follow-up study.
A sample of 66 first-episode psychotic patients was recruited and divided according to their diagnoses in affective and non-affective psychoses. Diagnoses were obtained with SCAN and DUP was registered for each patient. A clinical assessment for psychotic and affective symptoms was performed using standardized instruments.
All patient studied showed clinical improvement during follow-up. Patients with a longer DUP showed poorer psychosocial adjustment and lower recovery indexes. Treatment suspension was the main variable associated with relapse.
DUP is an important prognostic variable. Early detection programs are required to decrease the period between illness onset, diagnosis and treatment in first-episode psychotic patients.
特定治疗开始的延迟对精神病患者有若干预后影响。未治疗精神病持续时间（DUP）一直被视为一个预后变量。较长的DUP与不良临床结局相关。
在一项为期一年的随访研究中，确定首发精神病患者样本中的DUP及其与康复和复发的关系。
招募了66例首发精神病患者样本，并根据其诊断分为情感性和非情感性精神病。通过SCAN获得诊断，并为每位患者记录DUP。使用标准化工具对精神病和情感症状进行临床评估。
所有研究患者在随访期间均显示临床改善。DUP较长的患者表现出较差的社会心理适应和较低的康复指标。治疗中断是与复发相关的主要变量。
DUP是一个重要的预后变量。需要早期检测项目以缩短首发精神病患者从发病、诊断到治疗的时间间隔。
