1991 - 2002年英格兰和威尔士成年人细菌性脑膜炎流行病学的变化
Changing epidemiology of bacterial meningitis among adults in England and Wales 1991-2002.
作者信息
Gjini A B, Stuart J M, Lawlor D A, Cartwright K A V, Christensen H, Ramsay M, Heyderman R S
机构信息
Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, UK.
出版信息
Epidemiol Infect. 2006 Jun;134(3):567-9. doi: 10.1017/S0950268805005595.
We examined the epidemiology of community-acquired bacterial meningitis among adults in England and Wales between 1991 and 2002. Among 3169 cases, meningococcal infection was predominant among young adults and pneumococcal meningitis among older adults. Whilst infection due to most causes decreased, the incidence of tuberculous (TB) meningitis doubled over the 12 years. The mortality rate among meningococcal and pneumococcal infections fell from 0.45/10(5) to 0.31/10(5) (P=0.0001). This study demonstrates important changes in the epidemiology of bacterial meningitis among UK adults. Improvements in clinical management, childhood vaccination programmes and the re-emergence of tuberculosis are likely to be drivers of these changes.
我们研究了1991年至2002年间英格兰和威尔士成年人社区获得性细菌性脑膜炎的流行病学情况。在3169例病例中，脑膜炎球菌感染在年轻人中占主导，而肺炎球菌性脑膜炎在老年人中占主导。虽然大多数病因导致的感染有所减少，但结核性（TB）脑膜炎的发病率在这12年中翻了一番。脑膜炎球菌和肺炎球菌感染的死亡率从0.45/10⁵降至0.31/10⁵（P = 0.0001）。这项研究表明英国成年人细菌性脑膜炎的流行病学发生了重要变化。临床管理的改善、儿童疫苗接种计划以及结核病的再度出现可能是这些变化的驱动因素。
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