Hoen B
Département de maladies infectieuses et tropicales, CHU de Nancy, hôpitaux de Brabois, Vandoeuvre.
Rev Prat. 1994 Oct 15;44(16):2148-51.
In industrialized countries, the incidence of community-acquired bacterial meningitis is between 5 and 10 cases/10(5) population/year. The highest age-specific attack rates are recorded between 0 and 2 years of age and can reach 100 cases/10(5) population/year or more in some countries. In this range of age, Streptococcus agalactiae, Listeria monocytogenes and Escherichia coli are responsible for meningitis in neonates whereas Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae cause meningitis in children older than 1 month. H. influenzae was the leading cause of bacterial meningitis in children but its incidence has declined since the introduction of routine childhood immunization with conjugate vaccines. N. meningitidis is the leading cause of meningitis in teenagers and young adults, whereas S. pneumoniae is responsible for most of meningitis in the elderly. Prognosis of bacterial meningitis mainly depends on the type of causative organism and on the age of onset. Detailed epidemiologic features of Haemophilus, meningococcal and pneumococcal meningitis are provided.
在工业化国家,社区获得性细菌性脑膜炎的发病率为每10万人口每年5至10例。年龄特异性发病率最高的年龄段为0至2岁,在某些国家,该年龄段的发病率可达每10万人口每年100例或更高。在这个年龄段,无乳链球菌、单核细胞增生李斯特菌和大肠杆菌是新生儿脑膜炎的致病菌,而流感嗜血杆菌、脑膜炎奈瑟菌和肺炎链球菌则导致1个月以上儿童患脑膜炎。流感嗜血杆菌曾是儿童细菌性脑膜炎的主要病因,但自从引入常规儿童结合疫苗免疫接种后,其发病率有所下降。脑膜炎奈瑟菌是青少年和青年脑膜炎的主要病因,而肺炎链球菌则是老年人脑膜炎的主要致病菌。细菌性脑膜炎的预后主要取决于致病微生物的类型和发病年龄。本文提供了流感嗜血杆菌、脑膜炎球菌和肺炎球菌脑膜炎的详细流行病学特征。