Mansouri Parvin, Farshi Susan
Department of Dermatology, Tehran University of Medical Sciences, Imam Hospital, Keshavarz Blvd, Gharib St, Tehran, Iran.
Dermatol Online J. 2006 Feb 28;12(2):7.
Psoriasis is a chronic inflammatory skin disorder of multifactorial etiology. Because of the potential side effects of repeated topical application of potent corticosteroids, equally-effective, safer therapeutic options are required, especially in the treatment of children. We report on the efficacy of twice daily application of pimecrolimus 1 percent cream in a girl who suffered from psoriasis involving the eyelids and anogenital region. After 20 days of application of pimecrolimus cream the plaques completely resolved. No significant side effects have been observed. Topical pimecrolimus appears to be an effective and safe treatment for children with psoriasis. Our case observations provide further evidence for the beneficial effects of topical pimecrolimus in the treatment of psoriasis. Vehicle-controlled studies on a larger number of patients are now needed to investigate long-term efficacy and safety of topical pimecrolimus in the treatments of a variety of types of psoriasis in children.
银屑病是一种病因多因素的慢性炎症性皮肤病。由于反复局部应用强效皮质类固醇存在潜在副作用，因此需要有同等疗效且更安全的治疗选择，尤其是在儿童治疗方面。我们报告了一名患有累及眼睑和肛门生殖器区域银屑病的女孩，每日两次外用1%吡美莫司乳膏的疗效。应用吡美莫司乳膏20天后，斑块完全消退。未观察到明显副作用。外用吡美莫司似乎是治疗儿童银屑病的一种有效且安全的方法。我们的病例观察为外用吡美莫司治疗银屑病的有益效果提供了进一步证据。现在需要对更多患者进行赋形剂对照研究，以调查外用吡美莫司治疗儿童各种类型银屑病的长期疗效和安全性。
