Copenhagen Research Group for Inflammatory Skin (CORGIS), Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Acta Derm Venereol. 2023 Mar 14;103:adv00890. doi: 10.2340/actadv.v103.6525.
Facial and genital psoriasis impairs quality of life and is challenging to treat because of increased percutaneous penetration and, consequently, increased risk of adverse effects. Topical calcineurin inhibitors are recognized as a valid off-label treatment for these sensitive skin areas, but data on safety and efficacy are limited. This systematic review of the literature included 24 of 3,322 studies (5 randomized controlled trials, 9 open-label studies, 2 case series and 8 case reports). All studies demonstrated positive efficacy; 11 studies found statistically significant reductions in psoriasis severity. Local stinging, burning and itching were the most common short-term adverse effects and were reported in 18 studies. Topical calcineurin inhibitors appear to have an important role in the treatment of facial and genital psoriasis. The drugs are effective and generally well-tolerated with few adverse effects.
面部和生殖器银屑病会降低生活质量，且由于经皮渗透增加，不良反应风险相应增加，其治疗颇具挑战。外用钙调磷酸酶抑制剂被认为是这些敏感皮肤区域的有效超适应证治疗方法，但关于其安全性和疗效的数据有限。本系统文献复习共纳入了 3322 项研究中的 24 项（5 项随机对照试验、9 项开放标签研究、2 项病例系列研究和 8 项病例报告）。所有研究均显示出积极的疗效；11 项研究发现银屑病严重程度有统计学意义的降低。局部刺痛、灼热和瘙痒是最常见的短期不良反应，在 18 项研究中报告。外用钙调磷酸酶抑制剂似乎在治疗面部和生殖器银屑病方面具有重要作用。这些药物疗效确切，且通常具有良好的耐受性，不良反应较少。
