Donaldson M D, Vesey C J, Wilks M, Watson J D, Hinds C J
Anaesthetic Research Laboratory, St. Bartholomew's Hospital and Medical College, West Smithfield, London, England.
Circ Shock. 1991 Nov;35(3):152-8.
The cardiovascular and metabolic responses to treatment with ACTH(1-24) were investigated in a porcine model of septicaemia. Sixteen anaesthetised, instrumented animals were infused with live Escherichia coli over 2 hr. During the first hour of the infusion, significant reductions in cardiac index, mean arterial pressure, and pH were observed together with a significant increase in mixed venous blood lactate concentrations and packed cell volumes. ACTH(1-24) 160 micrograms kg-1, given 1 hr after starting the E. coli infusion (n = 8), had no significant effect on these haemodynamic or metabolic measurements when compared with the control group (n = 8). These results do not support the suggestion that intravenous ACTH(1-24) reverses cardiovascular depression in septicaemic shock.
在猪败血症模型中研究了促肾上腺皮质激素（1-24）治疗的心血管和代谢反应。16只麻醉并安装了仪器的动物在2小时内输注活的大肠杆菌。在输注的第一个小时内，观察到心脏指数、平均动脉压和pH值显著降低，同时混合静脉血乳酸浓度和红细胞压积显著增加。在开始输注大肠杆菌1小时后给予促肾上腺皮质激素（1-24）160微克/千克（n = 8），与对照组（n = 8）相比，对这些血流动力学或代谢测量指标没有显著影响。这些结果不支持静脉注射促肾上腺皮质激素（1-24）可逆转败血症性休克中心血管抑制的观点。
