Kauffman Robert P, Castracane V Daniel, Peghee Donald, Baker Teresa E, Van Hook James W
Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center School of Medicine, Amarillo, TX 79106, USA.
Am J Obstet Gynecol. 2006 Jun;194(6):1576-82; discussion 1582-4. doi: 10.1016/j.ajog.2006.01.010. Epub 2006 Apr 25.
We investigated whether homeostatic indices of insulin sensitivity might suitably screen for gestational diabetes mellitus.
One hundred twenty-three pregnant women who were between 24 and 28 weeks of gestation completed a 3-hour 100-g oral glucose challenge test and fasting insulin level in a nested case-control study design. Insulin sensitivity indices were calculated and tested for their ability to detect gestational diabetes mellitus.
Fasting glucose demonstrated the best overall accuracy, but the homeostasis model assessment and quick insulin sensitivity check index were also sensitive screening techniques for gestational diabetes mellitus when either the National Diabetes Data Group or Carpenter-Coustan criteria were used.
Homeostasis model assessment, quick insulin sensitivity check index, and fasting glucose are sensitive screening tests for gestational diabetes mellitus and can avoid oral administration of glucose-containing solutions.
我们研究了胰岛素敏感性的稳态指标是否适合用于筛查妊娠期糖尿病。
在一项巢式病例对照研究设计中，123名妊娠24至28周的孕妇完成了3小时100克口服葡萄糖耐量试验和空腹胰岛素水平检测。计算胰岛素敏感性指标并测试其检测妊娠期糖尿病的能力。
空腹血糖显示出最佳的总体准确性，但当使用国家糖尿病数据组或卡彭特-库斯坦标准时，稳态模型评估和快速胰岛素敏感性检查指数也是妊娠期糖尿病的敏感筛查技术。
稳态模型评估、快速胰岛素敏感性检查指数和空腹血糖是妊娠期糖尿病的敏感筛查试验，可避免口服含葡萄糖溶液。
