孕早期使用稳态模型评估-胰岛素抵抗指数诊断妊娠期糖尿病
Diagnosis of gestational diabetes mellitus by use of the homeostasis model assessment-insulin resistance index in the first trimester.
作者信息
Ozcimen Emel Ebru, Uckuyu Ayla, Ciftci Faika Ceylan, Yanik Filiz Fatma, Bakar Coskun
机构信息
Department of Obstetrics and Gynecology, Baskent University Hospital, Baskent, Turkey.
出版信息
Gynecol Endocrinol. 2008 Apr;24(4):224-9. doi: 10.1080/09513590801948416.
OBJECTIVE
Gestational diabetes mellitus (GDM) affects 2-10% of all pregnant women, causing increased morbidity and mortality, and is tested for in the second trimester of pregnancy. The purpose of the present study was to predict GDM in the first trimester.
DESIGN AND METHODS
The study included 271 patients who were between the 10th and 14th week of gestation. Fasting glucose and insulin were measured in the first trimester and the homeostasis model assessment-insulin resistance index (HOMA-IR) was calculated for each patient. These values were compared with the results of the second-trimester glucose tolerance test.
RESULTS
HOMA-IR values were higher in women with GDM. A cut-off value of 2.60 for HOMA-IR was calculated at the end of the study.
CONCLUSION
Accepting patients whose HOMA-IR value is higher than 2.60 in the first trimester seems to be a good method to predict GDM.
目的
妊娠期糖尿病（GDM）影响2%至10%的孕妇，导致发病率和死亡率增加，且在妊娠中期进行检测。本研究的目的是在妊娠早期预测GDM。
设计与方法
该研究纳入了271例妊娠10至14周的患者。在妊娠早期测量空腹血糖和胰岛素，并为每位患者计算稳态模型评估胰岛素抵抗指数（HOMA-IR）。将这些值与妊娠中期葡萄糖耐量试验的结果进行比较。
结果
GDM女性的HOMA-IR值更高。研究结束时计算出HOMA-IR的截断值为2.60。
结论
接受妊娠早期HOMA-IR值高于2.60的患者似乎是预测GDM的一种好方法。
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