Lunding Johan A, Tefera Solomon, Bayati Alfred, Gilja Odd Helge, Mattsson Hillevi, Hausken Trygve, Berstad Arnold
Section for Gastroenterology, Haukeland University Hospital, Institute of Medicine and National Centre of Ultrasound in Gastroenterology, Bergen, Norway.
Scand J Gastroenterol. 2006 May;41(5):544-52. doi: 10.1080/00365520500353723.
A new distension paradigm, by which the gastric volume response to ramp-tonic distension can be analysed in detail, has been developed. The aim of this study was to investigate the applicability of this new paradigm in man, and to compare pressure-induced gastric accommodation in healthy volunteers (HV) and patients with functional dyspepsia (FD).
Ten HV, and 11 FD patients were examined twice; once in the fasting state and once postprandially. Intragastric bag pressure was raised from 1 to 12 mmHg in 4 min (ramp phase) and then kept constant for 5 min (tonic phase).
Compared to HV, fasting FD patients had lower gastric accommodation rates (0.9+/-0.2 versus 2.5+/-0.4 ml/s, p=0.002), lower maximum volume (239+/-39 versus 428+/-64 ml, p=0.01) and a longer accommodation time (157+/-26 versus 92+/-15 s, p=0.03). A test meal prior to distension tended to normalize the response in FD patients.
This new barostat paradigm allowed detailed analysis of short-term pressure-induced accommodation in man. Impaired gastric distension-induced accommodation is a novel abnormality in FD.
已开发出一种新的扩张范式，借此可详细分析胃对斜坡-张力性扩张的容积反应。本研究旨在探讨这种新范式在人体中的适用性，并比较健康志愿者（HV）和功能性消化不良（FD）患者中压力诱导的胃适应性。
对10名HV和11名FD患者进行了两次检查；一次在空腹状态下，一次在餐后。胃内袋压力在4分钟内从1毫米汞柱升至12毫米汞柱（斜坡期），然后保持恒定5分钟（张力期）。
与HV相比，空腹FD患者的胃适应性率较低（0.9±0.2对2.5±0.4毫升/秒，p = 0.002），最大容积较低（239±39对428±64毫升，p = 0.01），适应性时间较长（157±26对92±15秒，p = 0.03）。扩张前的试验餐倾向于使FD患者的反应正常化。
这种新的压力调节器范式允许对人体短期压力诱导的适应性进行详细分析。胃扩张诱导的适应性受损是FD中的一种新异常。
