Coiro V, Capretti L, Bianconi L, Castelli A, Cerri L, Roberti G, Marcato A, Volpi R, Chiodera P
Cattedra di Clinica Medica Generale, Università di Parma, Italy.
Horm Metab Res. 1991 Dec;23(12):600-4. doi: 10.1055/s-2007-1003764.
The effects of sodium valproate (a drug enhancing endogenous gamma aminobutyric acid (GABA)-ergic activity) and of the GABA analog baclofen (a GABA B receptor agonist) on serum GH levels was tested in 8 type I diabetic men and 8 normal controls. Sodium valproate (800 mg) or baclofen (10 mg) were given by mouth at 08.30 h on the experimental day. Control tests with a placebo were performed on different occasions. Basal GH levels were similar in controls and diabetic patients. Sodium valproate induced a 7 fold increase in serum GH concentrations in both groups. In contrast, baclofen-induced GH rise was significantly higher in normal controls (mean peak was 3.4 times higher than baseline) than in diabetic patients (mean peak was only 2.1 times higher than basal value). Serum GH levels did not change after placebo administration in any groups. These data suggest the presence of diabetes-induced alterations of a GABAergic pathway mediated by B receptors in the control of GH secretion. Alternatively, the data might indicate a change in diabetic men of other baclofen-sensitive neurotransmissions, different from GABA.
在8名I型糖尿病男性患者和8名正常对照者中，测试了丙戊酸钠（一种增强内源性γ-氨基丁酸（GABA）能活性的药物）和GABA类似物巴氯芬（一种GABA B受体激动剂）对血清生长激素（GH）水平的影响。在实验当天的08:30口服给予丙戊酸钠（800毫克）或巴氯芬（10毫克）。在不同时间进行安慰剂对照试验。对照组和糖尿病患者的基础GH水平相似。丙戊酸钠使两组血清GH浓度增加了7倍。相比之下，巴氯芬诱导的GH升高在正常对照者中（平均峰值比基线高3.4倍）显著高于糖尿病患者（平均峰值仅比基础值高2.1倍）。在任何组中，给予安慰剂后血清GH水平均未改变。这些数据表明，在GH分泌的控制中，存在由B受体介导的糖尿病诱导的GABA能途径改变。或者，这些数据可能表明糖尿病男性中存在不同于GABA的其他对巴氯芬敏感的神经传递变化。
