Marchesi C, Chiodera P, De Ferri A, De Risio C, Dassó L, Menozzi P, Volpi R, Coiro V
Institute of Clinical Psychiatry, University of Parma, Italy.
Psychoneuroendocrinology. 1991;16(6):475-9. doi: 10.1016/0306-4530(91)90031-n.
In order to establish whether alterations in the GABAergic control of GH secretion occur in male patients with major depression, the GH response to the GABAergic-B agonist baclofen (10 mg PO at 0830h) or to placebo was tested in 9 depressed men and in 10 age- and weight-matched male normal controls. The basal concentrations of GH were significantly lower in the depressed patients (0.87 +/- 0.69 ng/ml) than in the normal controls (1.57 +/- 0.33 ng/ml) (p = 0.011) and were not modified by the administration of placebo. The administration of baclofen induced a striking, significant increase in GH concentrations in the normal controls (mean peak at 90 min = 6.4 +/- 1.5 ng/ml). In contrast, a slight, nonsignificant GH increase occurred in the depressed patients after baclofen (mean peak at 90 min = 1.57 +/- 1.45 ng/ml). The GH response was significantly lower in the depressed than in the control subjects (p less than 0.001). These data indicate the presence of reduced GABAergic control of GH secretion in male depressed patients.
为了确定重度抑郁症男性患者生长激素（GH）分泌的γ-氨基丁酸（GABA）能控制是否发生改变，对9名抑郁症男性患者和10名年龄及体重匹配的男性正常对照者进行了测试，观察他们对GABA能B类激动剂巴氯芬（上午8:30口服10毫克）或安慰剂的GH反应。抑郁症患者的GH基础浓度（0.87±0.69纳克/毫升）显著低于正常对照者（1.57±0.33纳克/毫升）（p = 0.011），且给予安慰剂后未发生改变。给予巴氯芬后，正常对照者的GH浓度出现显著大幅升高（90分钟时平均峰值 = 6.4±1.5纳克/毫升）。相比之下，抑郁症患者服用巴氯芬后GH有轻微升高，但无统计学意义（90分钟时平均峰值 = 1.57±1.45纳克/毫升）。抑郁症患者的GH反应显著低于对照者（p＜0.001）。这些数据表明男性抑郁症患者存在GH分泌的GABA能控制减弱的情况。
