情绪障碍中的药物遗传学
Pharmacogenetics in mood disorder.
作者信息
Nnadi Charles U, Goldberg Joseph F, Malhotra Anil K
机构信息
The Zucker Hillside Hospital, Glen Oaks, New York 11004, USA.
出版信息
Curr Opin Psychiatry. 2005 Jan;18(1):33-9.
PURPOSE OF REVIEW
Not all patients with mood disorder respond well to drug treatment. Emerging data suggest that genetic mechanisms could be involved. We searched the literature database and highlighted recent molecular genetic studies pertaining to drug response in mood disorders.
RECENT FINDINGS
Recent pharmacogenetic studies in mood disorders have reported generally positive findings supporting the view that genotyping may improve the confidence of prospectively identifying treatment response and adverse outcomes.
SUMMARY
The evidence documenting genotype-based response to drug treatment is rapidly expanding. Genes encoding target receptors and signal transduction systems may predict the efficacy of drug therapy in mood disorders. Additional predictors of treatment response in bipolar disorder may include the immediate early genes, mitochondrial genes and epigenetic mechanisms, although some of these studies are still preliminary.
综述目的
并非所有情绪障碍患者对药物治疗都有良好反应。新出现的数据表明，遗传机制可能与之相关。我们检索了文献数据库，并重点介绍了近期有关情绪障碍药物反应的分子遗传学研究。
近期发现
近期情绪障碍的药物遗传学研究普遍报告了阳性结果，支持基因分型可能会提高前瞻性识别治疗反应和不良结局的可信度这一观点。
总结
证明基于基因型的药物治疗反应的证据正在迅速增加。编码靶受体和信号转导系统的基因可能预测情绪障碍药物治疗的疗效。双相情感障碍治疗反应的其他预测因素可能包括即刻早期基因、线粒体基因和表观遗传机制，尽管其中一些研究仍处于初步阶段。
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