Pan Yu, Cheng Qi, Shan Mo-Shui, Yan Jin
Department of Psychology and Mental Health, Second Military Medical UniversityShanghai, China; Department of Medical Psychology, General Hospital of PLABeijing, China.
Department of Juvenile and Children's Behavioral Medicine, 102 Hospital of PLA Changzhou, China.
Int J Clin Exp Med. 2015 Oct 15;8(10):18837-42. eCollection 2015.
To explore the association between polymorphism of the norepinephrine transporter (NET) gene rs2242446 and rs5669 loci and depression in Chinese Han population.
A case-control study was carried out, the gene types and allele distributions of NFT gene rs2242446 and rs5569 loci in 302 depression patients and 302 healthy controls were detected by Taqman SNP genotyping technology.
The gene types and allele frequency distributions of NFT gene rs2242446 and rs5569 loci had significant differences between case group and control group (rs2242446, x(2)=26.045, P<0.05, x(2)=8.827, P<0.05, rs5569, x(2)=42.47, P<0.05, x(2)=20.9, P<0.05). The CC genotype of NET gene rs2242446 locus and rs5569 loci was a protective factor of depression compared with the CT and TT genotypes.
The NET genepoly morphism of rs2242446 and rs5569 loci was a ssociated with depression in Chinese Han population, in which the CC genotype of rs2242446 and rs5569 loci was a protective factor of depression.
探讨去甲肾上腺素转运体（NET）基因rs2242446和rs5669位点多态性与中国汉族人群抑郁症的关系。
进行病例对照研究，采用Taqman SNP基因分型技术检测302例抑郁症患者和302例健康对照者中NFT基因rs2242446和rs5569位点的基因类型和等位基因分布。
病例组与对照组在NFT基因rs2242446和rs5569位点的基因类型和等位基因频率分布存在显著差异（rs2242446，x(2)=26.045，P<0.05，x(2)=8.827，P<0.05；rs5569，x(2)=42.47，P<0.05，x(2)=20.9，P<0.05）。与CT和TT基因型相比，NET基因rs2242446位点和rs5569位点的CC基因型是抑郁症的保护因素。
NET基因rs2242446和rs5569位点多态性与中国汉族人群抑郁症相关，其中rs2242446和rs5569位点的CC基因型是抑郁症的保护因素。
