Jessup Rebecca L
Department of General Practice, Melbourne University, Carlton, Victoria, Australia.
Adv Skin Wound Care. 2006 Apr;19(3):138-47. doi: 10.1097/00129334-200604000-00009.
To identify and evaluate current mathematical formulas used to assess the rate of wound healing.
MEDLINE, CINAHL, and Cochrane Systematic Review databases, from 1965 to 2004.
Papers selected for the study met the following inclusion criteria: (1) participants had chronic venous, neuropathic, pressure, or ischemic wounds; (2) the wounds were objectively measured; and (3) the investigators described and used an objective measurement of wound healing rate, either as an absolute reduction in area over time, a percentage change, or a linear advancement of wound edge. Papers were excluded if they were (1) not written in English, (2) duplicated from other sources, or (3) unpublished.
In clinical trials, measurement of the rate of wound healing over time by using the equation for the linear advancement of wound margins toward the center of the wound controls for confounding introduced by differing baseline ulcer sizes and shapes. Use of this assessment method after 4 weeks of healing may prove to be of value in predicting time to complete healing. Further research is required to develop standard healing rates for wounds of different etiologies.
识别并评估当前用于评估伤口愈合速度的数学公式。
1965年至2004年的MEDLINE、CINAHL和Cochrane系统评价数据库。
入选本研究的论文符合以下纳入标准：（1）参与者患有慢性静脉性、神经性、压迫性或缺血性伤口；（2）伤口进行了客观测量；（3）研究者描述并使用了伤口愈合速度的客观测量方法，以面积随时间的绝对减少、百分比变化或伤口边缘的线性推进来表示。若论文（1）非英文撰写，（2）从其他来源重复获取，或（3）未发表，则予以排除。
在临床试验中，使用伤口边缘向伤口中心线性推进的公式来测量随时间变化的伤口愈合速度，可控制因基线溃疡大小和形状不同而产生的混杂因素。在愈合4周后使用这种评估方法可能对预测完全愈合时间具有价值。需要进一步研究来制定不同病因伤口的标准愈合速度。
