Nucleotide signaling in nervous system development.

The development of the nervous system requires complex series of cellular programming and intercellular communication events that lead from the early neural induction to the formation of a highly structured central and peripheral nervous system. Neurogenesis continuously takes place also in select regions of the adult mammalian brain. During the past years, a multiplicity of cellular control mechanisms has been identified, ranging from differential transcriptional mediators to inducers or inhibitors of cell specification or neurite outgrowth. While the identification of transcription factors typical for the stage-specific progression has been a topic of key interest for many years, less is known concerning the potential multiplicity of relevant intercellular signaling pathways and the fine tuning of epigenetic gene regulation. Nucleotide receptors can induce a multiplicity of cellular signaling pathways and are involved in multiple molecular interactions, thus opening the possibility of cross talk between several signaling pathways, including growth factors, cytokines, and extracellular matrix components. An increasing number of studies provides evidence for a role of nucleotide signaling in nervous system development. This includes progenitor cell proliferation, cell migration, neuronal and glial cellular interaction and differentiation, and synaptic network formation.