Seppi Klaus, Högl Birgit, Diem Anja, Peralta Cecilia, Wenning Gregor K, Poewe Werner
Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Mov Disord. 2006 Aug;21(8):1281-3. doi: 10.1002/mds.20898.
Recent observations suggest that levodopa can induce irresistible sleep onset in multiple system atrophy (MSA). Therefore, we assessed sleepiness during a levodopa challenge in 17 MSA compared with 23 Parkinson's disease (PD) patients using the Stanford Sleepiness Scale (SSS). SSS scores during the levodopa challenge compared with baseline were significantly increased in the MSA compared with the PD group. These findings suggest greater potential of levodopa to induce sleepiness in MSA compared with PD, which may be related to differences in basal ganglia and brainstem pathology between the two disorders.
近期观察结果表明，左旋多巴可在多系统萎缩（MSA）中诱发不可抗拒的睡眠发作。因此，我们使用斯坦福嗜睡量表（SSS）评估了17例MSA患者与23例帕金森病（PD）患者在左旋多巴激发试验期间的嗜睡情况。与基线相比，左旋多巴激发试验期间MSA组的SSS评分显著高于PD组。这些发现表明，与PD相比，左旋多巴在MSA中诱发嗜睡的可能性更大，这可能与这两种疾病之间基底神经节和脑干病理的差异有关。
