Abbott Sabra M, Videnovic Aleksandar
Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Mov Disord Clin Pract. 2014 Jun 1;1(2):89-96. doi: 10.1002/mdc3.12025.
Sleep disorders are commonly seen in atypical parkinsonism, with particular disorders occurring more frequently in specific parkinsonian disorders. Multiple systems atrophy (MSA) is a synucleinopathy often associated with nocturnal stridor which is a serious, but treatable condition highly specific to MSA. In addition, this disorder is strongly associated with rapid eye movement (REM) sleep behavior disorder (RBD), which is also seen in dementia with Lewy bodies (DLB). RBD is far less prevalent in progressive supranuclear palsy (PSP), which is a tauopathy. Insomnia and impaired sleep architecture are the most common sleep abnormalities seen in PSP. Corticobasilar degeneration (CBD) is also a tauopathy, but has far fewer sleep complaints associated with it than PSP. In this manuscript we review the spectrum of sleep dysfunction across the atypical parkinsonian disorders, emphasize the importance of evaluating for sleep disorders in patients with parkinsonian symptoms, and point to sleep characteristics that can provide diagnostic clues to the underlying parkinsonian disorder.
睡眠障碍在非典型帕金森病中很常见，特定的睡眠障碍在特定的帕金森病中更频繁地出现。多系统萎缩（MSA）是一种α-突触核蛋白病，常与夜间喘鸣有关，夜间喘鸣是一种严重但可治疗的疾病，对MSA具有高度特异性。此外，这种疾病与快速眼动（REM）睡眠行为障碍（RBD）密切相关，路易体痴呆（DLB）中也可见到RBD。RBD在进行性核上性麻痹（PSP，一种tau蛋白病）中发病率要低得多。失眠和睡眠结构受损是PSP中最常见的睡眠异常。皮质基底节变性（CBD）也是一种tau蛋白病，但与PSP相比，与之相关的睡眠主诉要少得多。在本手稿中，我们回顾了非典型帕金森病中睡眠功能障碍的范围，强调了对有帕金森症状的患者进行睡眠障碍评估的重要性，并指出了可为潜在帕金森病提供诊断线索的睡眠特征。
