Wilson Scott T, Fertuck Eric A, Kwitel Abbie, Stanley Melissa C, Stanley Barbara
Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA.
Int J Adolesc Med Health. 2006 Jan-Mar;18(1):189-96. doi: 10.1515/ijamh.2006.18.1.189.
Borderline Personality Disorder (BPD) is a severe and disabling psychiatric condition that typically emerges in late adolescence or early adulthood. Nearly 50% of individuals with BPD have a co-occurring Alcohol Use Disorder (AUD) at some point in the course of their illness. This study explores clinical characteristics of adolescents and young adults (age 30 years and younger) with BPD and AUD (N=21) compared to BPD without any history of substance use disorders (N=17). Based on theoretical considerations and previous findings, we hypothesized that adolescents and young adults with BPD and AUDs would be more impulsive and exhibit higher rates of suicidal behavior than individuals with BPD and no substance use disorders. Consistent with our first hypothesis, the BPD/AUD group was more impulsive than the BPD only group. However, the two groups did not differ on measures of suicidal behavior. Overall, impulsivity was correlated with total number of suicide attempts in the adolescent/young adult group. When older BPD participants were included in the comparison (up to age 55), the BPD/AUD group exhibited more lifetime suicide attempts that were higher in medical lethality than the BPD only group, suggesting an overall increased lifetime suicide risk in the BPD/AUD group. The relationship between impulsivity, AUD, and suicidal behavior and lifetime suicide risk in adolescent and young adults with BPD is discussed.
边缘型人格障碍(BPD)是一种严重且致残的精神疾病,通常在青春期晚期或成年早期出现。近50%的边缘型人格障碍患者在病程中的某个阶段会同时出现酒精使用障碍(AUD)。本研究探讨了患有边缘型人格障碍和酒精使用障碍的青少年和年轻人(30岁及以下,N = 21)与无物质使用障碍病史的边缘型人格障碍患者(N = 17)的临床特征。基于理论思考和先前的研究结果,我们假设患有边缘型人格障碍和酒精使用障碍的青少年和年轻人比无物质使用障碍的边缘型人格障碍患者更冲动,且自杀行为发生率更高。与我们的第一个假设一致,边缘型人格障碍/酒精使用障碍组比仅患有边缘型人格障碍的组更冲动。然而,两组在自杀行为测量方面没有差异。总体而言,冲动性与青少年/年轻人群体中的自杀未遂总数相关。当将年龄较大的边缘型人格障碍参与者纳入比较(最高55岁)时,边缘型人格障碍/酒精使用障碍组的终身自杀未遂次数更多,且医疗致死率更高,这表明边缘型人格障碍/酒精使用障碍组的终身自杀风险总体增加。本文讨论了边缘型人格障碍青少年和年轻人中冲动性、酒精使用障碍与自杀行为及终身自杀风险之间的关系。