英国环境性牛海绵状脑病风险评估的一项评价。

An evaluation of United Kingdom environmental bovine spongiform encephalopathy risk assessment.

作者信息

Grist Eric P M

机构信息

School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, United Kingdom.

出版信息

Integr Environ Assess Manag. 2005 Apr;1(2):152-9. doi: 10.1897/ieam_2004a-012.1.

DOI:10.1897/ieam_2004a-012.1

PMID:16639897

Abstract

As a member of the group of diseases known as transmissible spongiform encephalopathies (TSEs), bovine spongiform encephalopathy (BSE) has been causally associated with a new variant of Creutzfeldt-Jakob disease (vCJD) in humans. Given the many uncertainties on the transmission and persistence of TSE pathogens in the environment, quantitative assessment of risks to humans and animals continues to remain a public health issue. This paper reviews quantitative BSE risk assessments undertaken in the United Kingdom since 1997 to address the potential for human exposure and theoretical health risks through environmental pathways. The review focuses on how model assumptions and methodology may influence the results.

摘要

作为被称为传染性海绵状脑病（TSEs）的疾病群体的一员，牛海绵状脑病（BSE）已被证实与人类新型克雅氏病（vCJD）存在因果关系。鉴于TSE病原体在环境中的传播和持续性存在诸多不确定性，对人类和动物风险的定量评估仍然是一个公共卫生问题。本文回顾了自1997年以来在英国进行的BSE定量风险评估，以探讨人类通过环境途径接触BSE病原体的可能性以及理论健康风险。该综述重点关注模型假设和方法如何影响评估结果。